Bacterial co-infection and antibiotic stewardship in patients with COVID-19: a systematic review and meta-analysis

Abstract Introduction Understanding the proportion of patients with COVID-19 who have respiratory bacterial co-infections and the responsible pathogens is important for managing COVID-19 effectively while ensuring responsible antibiotic use.Objective To estimate the frequency of bacterial co-infection in COVID-19 hospitalized patients and of antibi

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Twisting and swiveling domain motions in Cas9 to recognize target DNA duplexes, make double-strand breaks, and release cleaved duplexes

The CRISPR-associated protein 9 (Cas9) has been engineered as a precise gene editing tool to make double-strand breaks.CRISPR-associated protein 9 binds the folded guide RNA (gRNA) that serves as a binding scaffold to guide it to the target DNA duplex via a RecA-like strand-displacement mechanism but without ATP Bedding Set binding or hydrolysis.Th

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